# E2B Projects at AI Tinkerers

> Canonical HTML: https://aitinkerers.org/technologies/e2b
> Markdown URL: https://aitinkerers.org/technologies/e2b.md
> Technology record last updated: 2026-09-18T15:13:47Z
> Generated: 2026-09-23T07:35:11Z

E2B is the International Council for Harmonisation (ICH) standard for the electronic transmission of Individual Case Safety Reports (ICSRs) in pharmacovigilance.

E2B is the critical technical standard (ICH M1) that mandates the format, content, and structure for electronically exchanging drug safety data globally. The current iteration, E2B(R3), specifies the XML message structure and over 100 data elements: patient demographics, adverse event details, and product information. This standard ensures pharmaceutical companies and regulatory bodies—like the FDA and EMA—can transmit ICSRs (Individual Case Safety Reports) efficiently through secure electronic gateways, facilitating rapid analysis and signal detection to protect public health.

- Official technology site: https://www.ich.org/page/ich-e2b-r3-individual-case-safety-report-icsr-specification-and-related-files
- Public AI Tinkerers demos and talks: 3
- Result page: 1 of 1

## Recent Public Talks and Demos

### [Boomerang: why I built my own agentic browser infra](https://cologne.aitinkerers.org/talks/rsvp_XEuIAGK7fdA)

I built a replacement for browserbase, notte, firecrawl and the many other agentic web-use browser infra providers. I walk through the story of trying out various systems, then deciding to build my own, the trials and tribulations of battling cloudflare, how agents go wrong, and more.

- Event context: AI Tinkerers Cologne 4: Live Technical Demos — 2026-04-16 — Cologne
- Public talk page: https://cologne.aitinkerers.org/talks/rsvp_XEuIAGK7fdA

### [Sentinel - AI Document Intelligence for Regulated Teams](https://dc.aitinkerers.org/talks/rsvp_dme7MO875dE)

Sentinel is an AI document intelligence agent that helps regulated teams review complex documents faster by cross-referencing them against trusted evidence, surfacing risks and obligations, and producing outputs that are fully traceable and defensible.

- Event context: AI Tinkerers x Softengi - DC Metro Meetup - April 9th, 2026 — 2026-04-09 — DC
- Public talk page: https://dc.aitinkerers.org/talks/rsvp_dme7MO875dE

### [SandboxJS: Terraform for AI Sandboxes](https://sf.aitinkerers.org/talks/rsvp_sUu99YMS6gU)

I created an open source library for quickly building agents on any AI sandbox provider. It abstracts the basic functions of a sandbox (running code, building from a Dockerfile, etc.) for building computer use agents, coding agents, and reasoning agents. I'll also share my thoughts on the world of open source code sandboxes based on my contributions at E2B, Daytona, and Cua.

- Event context: AI Infra Jam: Demos That Weren’t Possible Two Months Ago — 2025-09-25 — San Francisco
- Public talk page: https://sf.aitinkerers.org/talks/rsvp_sUu99YMS6gU

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