# ESM2 Projects at AI Tinkerers

> Canonical HTML: https://aitinkerers.org/technologies/esm2
> Markdown URL: https://aitinkerers.org/technologies/esm2.md
> Technology record last updated: 2026-03-04T04:48:18Z
> Generated: 2026-10-25T15:41:00Z

Meta AI's transformer-based language model that predicts protein structure and function directly from amino acid sequences.

ESM2 represents the state of the art in protein language modeling, trained on 250 million protein sequences to achieve atomic-level resolution. By leveraging a transformer architecture with up to 15 billion parameters, it outperforms previous iterations like ESM-1b in predicting secondary structures and long-range contacts. Researchers use ESM2 to accelerate drug discovery and protein engineering, as it generates high-accuracy 3D structures (ESMFold) orders of magnitude faster than AlphaFold2.

- Official technology site: https://github.com/facebookresearch/esm
- Public AI Tinkerers demos and talks: 1
- Result page: 1 of 1

## Recent Public Talks and Demos

### [Meta Modeling for drug discovery.](https://dc.aitinkerers.org/talks/rsvp_SBMb6DF9kMI)

- Event context: AI Tinkerers - DC Metro Meetup - February 24th, 2026 — 2026-02-24 — DC
- Public talk page: https://dc.aitinkerers.org/talks/rsvp_SBMb6DF9kMI

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