# Senolytics Projects at AI Tinkerers

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> Technology record last updated: 2026-03-25T08:18:10Z
> Generated: 2026-09-22T09:42:42Z

Senolytics are a class of selective therapeutics designed to induce apoptosis in non-dividing, pro-inflammatory 'zombie' cells to reverse age-related tissue dysfunction.

Senolytics target cellular senescence, a state where damaged cells stop dividing but remain metabolically active, secreting a toxic mix of inflammatory proteins known as the SASP. By inhibiting specific anti-apoptotic pathways (SCAPs) like BCL-xL and p21, these drugs force 'zombie' cells into programmed death without harming healthy neighbors. Clinical momentum is building through trials at the Mayo Clinic and firms like Unity Biotechnology, testing compounds such as Dasatinib, Quercetin, and UBX1325. Early human data shows promise in treating localized conditions like diabetic macular edema and systemic issues like idiopathic pulmonary fibrosis. With the global senolytics market projected to hit $12.3 billion by 2032, the shift from managing symptoms to clearing the cellular 'root cause' of aging is officially underway.

- Official technology site: https://www.mayoclinic.org/medical-professionals/geriatrics/news/senolytic-drugs-from-discovery-to-translation/mac-20502123
- Public AI Tinkerers demos and talks: 1
- Result page: 1 of 1

## Recent Public Talks and Demos

### [Changing your DNA for health and longevity](https://ee.dream.page/talks/rsvp_j2k5pl9Ybm0)

Oisin Biotechnologies is a company dedicated to developing genetic medicines that address a range of age-related diseases. Their lead candidate aims to build muscle without exercise, which could be used as a therapy to make older people stronger. The company also has assets that selectively kill adipocytes and senescent cells, which are believed to play a significant role in the aging process and the onset of age-related diseases. Oisin has generated impressive data and has already licensed its technology to pharmaceutical companies.

- Event context: Bellevue+Eastside Entrepreneurs - October 5, 2023 Event — 2023-10-05 — Eastside Entrepreneurs
- Public talk page: https://ee.dream.page/talks/rsvp_j2k5pl9Ybm0

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